Pharmacology 3 Flashcards
1
Q
4 components of pharmacokinetics (PK)
A
ADME
Absorption
Distribution
Metabolism
Excretion
2
Q
different absorption / routes of administration
A
Oral (Per os)
Injection (parenteral)
Inhalation
Mucous membranes
Transfermal
3
Q
Parameters determining permeation
A
A. Aqueous diffusion
B. Lipid diffusion
C. Transporters and carriers
D. endocytosis and exocytosis
4
Q
What is the relation between lipid solubility (octanol/water partition coefficient) and absorption
A
the more lipid soluble will have a better absoprtion
5
Q
Ionized (charged) molecules have ___ permeability across lipid membranes
A
lower
- basically it needs to bu uncharged to penetrate
6
Q
A
