Pharmacology

Question 0

0 order kinetics

Answer 0

Constant amt of drug eliminated regardless of dose

Question 1

Drugs that do not pass thru liver first

Answer 1

Sublingual and rectal

Question 2

1st order kinetics

Answer 2

Drug eliminated proportional to dose

Question 3

Gout

Answer 3

Caused by build up of uric acid- end product of purine metabolism

Question 4

Treatment for gout

Answer 4

Colchicine- Antiinflamm, binds tublin, no migration
Indomethacin- anti inflamm
Allopurinol- xanthine oxidase inhibitor- for over producers
Probenecid - inc renal secretions for undersecreters

Question 5

GI Drugs

Answer 5

Promethazine: phenergan: tardive dyskinesia tx: benedryl

Metoclopramide: reglan: dopamine blocker- can increase gastric motility

Ondansetron: zofran: serotonin rec inhibitor

Ompreazole: proton pump inhibitor- block H/ATPase in stomach

Cimetidine: histamine blocker- dec acid in stomach
Octreotide: somatostatin analog

Question 6

Cardiac drugs: digoxin

Answer 6

Digoxin: inhibit Na/K, inc myocardial Ca
Slows AV conduction
Inotrope
Dec BF to intestine-mes ischemia
Hypokalemia
Not cleared w/dialysis
SE: yellow vision, arrhythmia

Question 7

Cardiac drugs: procainmide

Answer 7

SE: lupus like synd, pulm fibrosis, torsades
(Tx torsades with Mg)
Follow QT intervals

Question 8

Ace inhibitors- pril

Answer 8

Best to reduce mortality in CHF
Prevent post CHF MI
Prevent renal failure progression
Can cause renal failure in renal artery stenosis