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Antibiotics Flashcards

0
Q

Inhibitors of the 30s ribosome

A

Tetracycline
Aminoglycosides (tobramycin, gentamicin)
Linezolid

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1
Q

Inhibitors of cell wall synthesis

A

PCN, cephalosporin,carbapenems

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2
Q

Inhibitors of the 50s ribosome

A

Erythromycin

Clindamycin

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3
Q

Inhibitor of the DNA Helicase (DNA Gyrase)

A

Quinolones

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4
Q

Produces oxygen radicals that break up DNA

A

Metronidazole - flagyl

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5
Q

Bacteriostatic abx

A 
Tetracycline
Clindamycin
Erythromycin
Bactrim
Chloramphenicol
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6
Q

PCN is good for…..

A

GPCs- strep, syphilis, neisseria meningitides, clostridium Perfringes, beta hemo strep, antrax

NOT effective against staph or enterococcus

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7
Q

PCN that works on enterococcus

A

Ampicillin/ amoxicillin

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8
Q

Unasyn ( ampicillin/sulbactam) and augmentin ( amoxicillin/ clavulanic acid) are good for….

A

Broad spectrum
GPC (staph/strep)
GNR
Enterococcus

NOT for pseudomonas, acinetobacter, serratia

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9
Q

Good for pseudomonas

A

Ticarcillin/ piperacilin

Good for: GNR- pseudomonas, acinetobacter, serratia

Side effects:inhibits platelets

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10
Q

1st generation cephalosporin ( cefazolin, cephalexin) good for…..

A

GPC- staph and strep
Ancef- cefazolin- longest half life-good for ppx

NOT for enterococcus

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11
Q

2nd generation cephalosporins - cefoxitin, cefotetan, cefuroxime good for…..

A

GPC
GNR
+/- anaerobic

Not for enterococcus, pseudomonas actinobacter serratia

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12
Q

3rd gen cephalosporins ( ceftriaxone, cefepime, cefotaxime) good for….

A

GNR
+/- anaerobes

Not enterococcus pseudomonas actinobacter serratia

Side effects: ceftriaxone- chokes tactic jaundice, sludging of gallbladder

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13
Q

Quinolones -cipro, levo good for…..

A

GPC
GNR

Yes: pseudomonas, acinetobacter, serratia

NOT: enterococcus

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14
Q

Clindamycin is good for….

A

Anaerobes
Asp PNA
Can tx clostridium Perfringes

Side effect: pseudomembraneous colitis

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15
Q

Effective against pseudomonas acinetobacter serratia

A 
Ticarcillin/piperacilin 
3rd gen cephalosporins
Aminoglycosides- genta, tobramycin 
Meropenem/imipenem
Flouroquinolones
16
Q

Tetracycline can interfere with….

A

Beta-lactams

17
Q

Anti fungal drugs….

A

Amphotericin- binds sterols, alters memb permb
SE: kidney toxic, fever, dec K, hypotension, anemia
Use with poss sepsis due to fungal infection

Fluconazole
Ketoconazole

18
Q

Anti-TB drugs

A 
RIPE
Rifampin: inhib RNA polymerase
Isoniazid: inhibits mycolic acids
Pyrazinamide: se- hepatotoxic
Ethambutol: se-retrobulbar neuritis
19
Q

Antiviral drugs

A

Acyclovir: inhibits DNA polymerase

Ganciclovir: used for CMV infections
SE: dec bone marrow, CNS toxicity

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