Pharmacology 2 Flashcards

1
Q

Name 2 types of receptors

A

Nicotinic receptors

Muscarinic receptors

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2
Q

Where are nicotinic receptor?

A

Found in skeletal muscle ganglia CNS

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3
Q

What is the nicotinic receptor structure?

A

pentameric structure many subunits combinations

Ligand gated Na+ channel

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4
Q

Where are muscarinic receptors ?

A

Found in intestinal smooth muscle heart blood vessels salivary glands CNS

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5
Q

How many known subtypes to the muscarinic receptor

A

5

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6
Q

What are muscarinic receptors coupled with?

A

G-protein

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7
Q

What activates and blocks Nicotinic receptors?

A

Activated by nicotine

Blocked by d-tubocurarine

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8
Q

What activates and blocks Muscarinic receptors?

A

Activated muscarine

Blocked by atropine

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9
Q

What are the subunits in adult muscle nicotinic receptors?

A

2x Alpha
beta
gama
delta

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10
Q

How many types of Alpha and Beta subunits are there on nicotinic receptors?

A

8 Alpha

4 Beta

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11
Q

Name the Nicotinic receptor antagonist NMJ

A

Decamethonium

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12
Q

Name the Nicotinic receptor antagonist at ganglia

A

Hexamethonium

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13
Q

Name the substance that blocks at NMJ but not a neuronal receptors

A

Alpha-bungaratoxin

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14
Q

What is epibatidine?

A

Selective antagonist of neuronal nicotinic receptor

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15
Q

How does having an R group of C2H5 affect the potency and classification of the molecules?

A
R1 =	C2H5 - 25% potency
	partial agonist
R1 = R2 = C2H5 0.03% potency 
	partial agonist
R1 = R2 = R3 = C2H5 no agonist activity, 	weak antagonist
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16
Q

What 4 structural factors affect drug ability

A

Charge
Methyl Group
Ester linkages
Distance

17
Q

On a nicotinic receptor what does addition of alpha-methyl mean?

A

Retains activity
R-isomer 4% activity
S=isomer 1%

18
Q

On a nicotinic receptor what does addition of beta-methyl mean?

A

Nicotinic inactive
S-isomer fully active
R isomer 1% active

19
Q

What are the 3 types of Histamine receptor subtypes

A

H1- produces vasodilation
H2- stimulates gastric acid secretion
H3- presynaptic receptor

20
Q

Name an example of an inhibitory amino acid transmitters

A

GABA
Muscimol
Baclofen

21
Q

Name an example of an excitatory amino acid transmitter

A

Glutamate

Aspartate

22
Q

Name 3 excitatory amino acid transmitters receptors that are ionotropic receptors

A

NMDA
Kainate
AMPA

23
Q

AP4 receptor is a m_____ receptor causing increased c____ and release of c____

A

AP4 receptor is a metabotropic receptor causing increased cAMP and release of Ca2+

24
Q

GABA is the m___ i____ neurotransmitter in the CNS

A

major inhibitory neurotransmitter

25
Q

What are the 2 major receptor subtypes on the GABA neurotransmitter ?

A

GABA2 ligand gated chloride channel

GABAB G coupled receptor which decreases cAMP

26
Q

Name an agonist and antagonist for GABA1

A
Agonist= muscimol
Antagonist= bicuculline
27
Q

Name the agonist for GABA2

A

Baclofen

28
Q

Which dopamine receptors increase and decrease cAMP

A

D1 and D5 increase cAMP

D2, D3 and D4 decreases cAMP

29
Q

Name a general agonist for 5HT1 receptors

A

Erotamine

30
Q

Which adrenergic receptor subtype is for Asthma?

A

Salbutamol- beta 2