Pharmacology 2

Question 1

Name 2 types of receptors

Answer 1

Nicotinic receptors

Muscarinic receptors

Question 2

Where are nicotinic receptor?

Answer 2

Found in skeletal muscle ganglia CNS

Question 3

What is the nicotinic receptor structure?

Answer 3

pentameric structure many subunits combinations

Ligand gated Na+ channel

Question 4

Where are muscarinic receptors ?

Answer 4

Found in intestinal smooth muscle heart blood vessels salivary glands CNS

Question 5

How many known subtypes to the muscarinic receptor

Answer 5

5

Question 6

What are muscarinic receptors coupled with?

Answer 6

G-protein

Question 7

What activates and blocks Nicotinic receptors?

Answer 7

Activated by nicotine

Blocked by d-tubocurarine

Question 8

What activates and blocks Muscarinic receptors?

Answer 8

Activated muscarine

Blocked by atropine

Question 9

What are the subunits in adult muscle nicotinic receptors?

Answer 9

2x Alpha
beta
gama
delta

Question 10

How many types of Alpha and Beta subunits are there on nicotinic receptors?

Answer 10

8 Alpha

4 Beta

Question 11

Name the Nicotinic receptor antagonist NMJ

Answer 11

Decamethonium

Question 12

Name the Nicotinic receptor antagonist at ganglia

Answer 12

Hexamethonium

Question 13

Name the substance that blocks at NMJ but not a neuronal receptors

Answer 13

Alpha-bungaratoxin

Question 14

What is epibatidine?

Answer 14

Selective antagonist of neuronal nicotinic receptor

Question 15

How does having an R group of C2H5 affect the potency and classification of the molecules?

Answer 15

R1 =	C2H5 - 25% potency
	partial agonist
R1 = R2 = C2H5 0.03% potency 
	partial agonist
R1 = R2 = R3 = C2H5 no agonist activity, 	weak antagonist

Question 16

What 4 structural factors affect drug ability

Answer 16

Charge
Methyl Group
Ester linkages
Distance

Question 17

On a nicotinic receptor what does addition of alpha-methyl mean?

Answer 17

Retains activity
R-isomer 4% activity
S=isomer 1%

Question 18

On a nicotinic receptor what does addition of beta-methyl mean?

Answer 18

Nicotinic inactive
S-isomer fully active
R isomer 1% active

Question 19

What are the 3 types of Histamine receptor subtypes

Answer 19

H1- produces vasodilation
H2- stimulates gastric acid secretion
H3- presynaptic receptor

Question 20

Name an example of an inhibitory amino acid transmitters

Answer 20

GABA
Muscimol
Baclofen

Question 21

Name an example of an excitatory amino acid transmitter

Answer 21

Glutamate

Aspartate

Question 22

Name 3 excitatory amino acid transmitters receptors that are ionotropic receptors

Answer 22

NMDA
Kainate
AMPA

Question 23

AP4 receptor is a m_____ receptor causing increased c____ and release of c____

Answer 23

AP4 receptor is a metabotropic receptor causing increased cAMP and release of Ca2+

Question 24

GABA is the m___ i____ neurotransmitter in the CNS

Answer 24

major inhibitory neurotransmitter

Question 25

What are the 2 major receptor subtypes on the GABA neurotransmitter ?

Answer 25

GABA2 ligand gated chloride channel | GABAB G coupled receptor which decreases cAMP

Question 26

Name an agonist and antagonist for GABA1

Answer 26

``` Agonist= muscimol Antagonist= bicuculline ```

Question 27

Name the agonist for GABA2

Answer 27

Baclofen

Question 28

Which dopamine receptors increase and decrease cAMP

Answer 28

D1 and D5 increase cAMP | D2, D3 and D4 decreases cAMP

Question 29

Name a general agonist for 5HT1 receptors

Answer 29

Erotamine

Question 30

Which adrenergic receptor subtype is for Asthma?

Answer 30

Salbutamol- beta 2