Pharmacology 2 Flashcards
Name 2 types of receptors
Nicotinic receptors
Muscarinic receptors
Where are nicotinic receptor?
Found in skeletal muscle ganglia CNS
What is the nicotinic receptor structure?
pentameric structure many subunits combinations
Ligand gated Na+ channel
Where are muscarinic receptors ?
Found in intestinal smooth muscle heart blood vessels salivary glands CNS
How many known subtypes to the muscarinic receptor
5
What are muscarinic receptors coupled with?
G-protein
What activates and blocks Nicotinic receptors?
Activated by nicotine
Blocked by d-tubocurarine
What activates and blocks Muscarinic receptors?
Activated muscarine
Blocked by atropine
What are the subunits in adult muscle nicotinic receptors?
2x Alpha
beta
gama
delta
How many types of Alpha and Beta subunits are there on nicotinic receptors?
8 Alpha
4 Beta
Name the Nicotinic receptor antagonist NMJ
Decamethonium
Name the Nicotinic receptor antagonist at ganglia
Hexamethonium
Name the substance that blocks at NMJ but not a neuronal receptors
Alpha-bungaratoxin
What is epibatidine?
Selective antagonist of neuronal nicotinic receptor
How does having an R group of C2H5 affect the potency and classification of the molecules?
R1 = C2H5 - 25% potency partial agonist R1 = R2 = C2H5 0.03% potency partial agonist R1 = R2 = R3 = C2H5 no agonist activity, weak antagonist