Pharmacology

Question 1

Which drug can cause ototoxicity and nephrotoxicity?

Which disease is it contrindicated in?

Answer 1

Gentamicin

Myasthenia Gravis

Question 2

How do you treat beta blocker overdose? What if 1st line doesn’t work?

Answer 2

Give atropine if bradycardic

If doesn’t work, give IV glucagon
(acts on glucagon receptors on heart, bypassing beta blockade)

Question 3

How do you treat aspirin overdose? What are the criteria for haemodialysis?

Answer 3

IV bicarbonate

Haemodialysis criteria are acidosis, pulmonary oedema, seizure, coma..

Question 4

What are the symptoms of CO poisoning?

Answer 4

Headache, confusion

Nausea vomiting

Cherry pink lips/mucosa

History of student accommodation/poorly maintained housing

Question 5

Which investigation in suspected CO poisoning?

Answer 5

ABG!

Not pulse oximetry (will be artificially high from CO)

Question 6

What symptoms does pesticide poisoning cause and why?

Answer 6

parasympathetic overactivation…
(because it inhibits acetylcholinesterase)
so increase in ACh

bradycardia
salivation
lacrimation
urination
diarrhoea

Question 7

How to treat pesticide poisoning?

Answer 7

Atropine

Question 8

Symptoms of lithium toxicity?

Answer 8

Coarse tremor
Confusion
Hyperreflexia

Question 9

Which NSAID is contra-indicated in CVS/VAscular disease?

Answer 9

Diclofenac!

Question 10

Definition of prolonged QTc?

Answer 10

men >440
women >460

> 500 = increased risk TdP

Question 11

Enzyme inducers

Answer 11

CRAP GPS induces rage
(St Johns wort)

Question 12

Enzyme inhibitors

Answer 12

SICKFACE.COM Group

(Grapefruit juice)

Question 13

What is danger of TCA overdose?
How do you treat overdose?

Answer 13

Metabolic acidosis and heart arrhythmia

Therefore, IV bicarbonate