Pharmacology Flashcards
What side effect of amiodarone to patients need to be aware of?
Pulmonary fibrosis
Which medications can precipitate lithium toxicity?
Diuretics (especially thiazides)
ACE inhibitors/angiotensin II receptor blockers
NSAIDs
Metronidazole
How is unfractioned heparin monitored?
APTT
Which antibiotic lowers seizure threshold?
Ciprofloxacin
Which medications used in combination with digoxin can precipitate digoxin toxicity?
Amoiodarone
Verapamil
Diltiazem
Spironolactone
Ciclosporin
Thiazides and loop diuretics
Which electrolyte abnormalities can precipitate digoxin toxicity?
Hypomagnesaemia
Hypokalaemia
Hypercalcaemia
Hypernatraemia
Trastuzumab (Herceptin) is a monoclonal antibody directed against the HER2/neu receptor. It is used mainly in metastatic breast cancer - what side effect is important to be aware of?
Cariotoxicity - therefore patients require an ECHO before starting it
How does organophosphate (insecticide) poisoning present?
D: defaecation & diaphoresis.
U: urinary incontinence.
M: miosis (pupil constriction).
B: bradycardia
E: emesis.
L: lacrimation.
S: salivation.
Management is with atropine!
What is the treatment for iron tablet overdose?
Desferrioxamine
What is the treatment for anti-freeze ingestion?
Fomepizole
What are the side effects of ciprofloxacin?
Lowers seizure threshold
Tendon damage
Lengthens QT
How does lithium toxicity present?
Coarse tremor (a fine tremor is seen in therapeutic levels)
Hyperreflexia
Acute confusion
Polyuria
Seizure
