pharmacology

Question 1

ace inhbitors side effects

Answer 1

Side-effects:
* cough
occurs in around 15% of patients and may occur up to a year after starting treatment
thought to be due to increased bradykinin levels
* angioedema: may occur up to a year after starting treatment
* hyperkalaemia
* first-dose hypotension: more common in patients taking diuretics

Question 2

indapamide side effects

Answer 2

Thiazide diuretics can cause hypercalcaemia and hypocalciuria

Question 3

A 61-year-old man with peripheral arterial disease is prescribed simvastatin. What is the most appropriate blood test monitoring?

Answer 3

LFTs at baseline, 3 months and 12 months. might also do fasting lipid profile

Question 4

SSRI use during third trimester - risk of

Answer 4

SSRI use during third trimester - risk of persistent pulmonary hypertension of the newborn

Question 5

Cautions and contraindications ACE

Answer 5

Cautions and contraindications
* pregnancy and breastfeeding - avoid
* renovascular disease - may result in renal impairment
* * aortic stenosis - may result in hypotension
* hereditary of idiopathic angioedema
* specialist advice should be sought before starting ACE inhibitors in patients with a potassium >= 5.0 mmol/L

Question 6

ACE interactions

Answer 6

patients receiving high-dose diuretic therapy (more than 80 mg of furosemide a day)
* significantly increases the risk of hypotension

Question 7

Rivaroxaban and apixaban can be reversed by

Answer 7

Rivaroxaban and apixaban can be reversed by andexanet alfa

Question 8

which antibiotics should be avoided in in pregnant or breastfeeding women and in children younger than 12 years of age

Answer 8

Oral tetracyclines should be avoided in pregnant or breastfeeding women and in children younger than 12 years of age