Haematology

Question 1

the mainstay of treatment in haemochromatosis

Answer 1

Regular venesection is the mainstay of treatment in haemochromatosis

Question 2

polycythaemia vera features

Answer 2

Raised haemoglobin, plethoric appearance, pruritus, splenomegaly, hypertension → ?polycythaemia vera

Question 3

the characteristic iron study profile in haemochromatosis

Answer 3

Raised transferrin saturation and ferritin, with low TIBC is the characteristic iron study profile in haemochromatosis

Question 4

chronic myeloid leukemia presentation

Answer 4

passmed question: raised plateletes, raised neutrohils, raised WCC but normal lymphocytes. weightloss,fatigue

Question 5

Pernicious anaemia predisposes to

Answer 5

Pernicious anaemia predisposes to gastric carcinoma

Question 6

Pernicious anaemia definition

Answer 6

Pernicious anaemia is an autoimmune disorder affecting the gastric mucosa that results in vitamin B12 deficiency.

Question 7

Pernicious anaemia pathophysiology

Answer 7

Question 8

Pernicious anaemia RF

Answer 8

• more common in females (F:M = 1.6:1) and typically develops in middle to old age
• associated with other autoimmune disorders: thyroid disease, type 1 diabetes mellitus, Addison’s, rheumatoid and vitiligo
• more common if blood group A

Question 9

Pernicious anaemia features

Answer 9

Question 10

Pernicious anaemia investigations

Answer 10

Question 11

Pernicious anaemia management

Answer 11

Question 12

Pernicious anaemia complications

Answer 12

Complications other than the haematological and neurological features detailed above:
increased risk of gastric cancer

Question 13

iron deficiency anemia blood test profile

Answer 13

low tranferrin saturation
low ferritin
high TIBC

Question 14

Acute chest syndrome definition

Answer 14

Acute chest syndrome is a complication of sickle-cell disease and presents with dyspnoea, chest pain, cough, hypoxia and new pulmonary infiltrates seen on chest x-ray