Pharmacology

Question 1

Equation for volume of distribution (Vd)

Answer 1

Vd of plasma protein-bound drugs can be altered by liver/ kidney disease (decrease protein binding -> Increase Vd)

Question 2

Equation for clearance (Cl)

Answer 2

Cl = rate of elimination of drug/plasma concentration

Question 3

Equation for Loading dose?

Equation for maintance dose?

Answer 3

Renal/kidney disease decreases maintaince dose but loading dose is unaffected

Question 4

What is Km? Vmax?

Answer 4

Decrease Km -> Increase affinity

Question 5

Km and Vmax on Lineweaver-Burk plot?

Answer 5

Question 6

Competitive vs Non-competitive Inhibitor Graph?

Answer 6

Question 8

Photosensitivity Drugs

Answer 8

SAT for a photo

Sulfonimides

Amiodarone

Tetracyclines

Question 9

SLE-like syndromes

Answer 9

SHIPP

Sulfonamide

Hydralazine

INH

Procainamide

Phenytonin

Question 10

P450 Inducer

Answer 10

“BCG PQRS”

Barbituates
Carbamazepine
Griseofulvin

Phenytoin
Quinidine
Rifampin
St John Worts

Question 11

P450 Inhibitors

Answer 11

“PICK EGS”

(HIV) Protease inhibitor
INH
Cimetidine
Ketoconazole

Erythromycin
Grapefruit juice
Sulfonamide

Question 12

Rash (Steven Johnson’s Syndrome)

Answer 12

Ethosuximide, lamotrigine, carbamazepine phenobarbital (seizsure drugs)
Phenytoin
Sulfa drugs
Penicllin
Allopurinol