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Addiction Medicine Board Study > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

1) THC metabolism
2) drugs that increase THC effect

A

1) CYP2C19, CYP3A4, CYP2C9
2) fluoxetine, ketoconazole

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2
Q

BZD mechanism of action

A

facilitates inhibition at GABA receptors

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3
Q

CYP2D6 plays a role in what opiate/opioid metabolism?

A

1) codeine –> morphine
2) hydrocodone –> hydromorphone
3) oxycodone –>oxymorphone
4) noroxycodone –> noroxymorphone

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4
Q

Ketamine mechanisms of action

A

mainly non-competitive antagonist at NMDA glutamate receptor

also
- antagonist at muscarinic and nicotinic acetylcholine receptors
- block sodium and potassium channels
- activate high-affinity D2 dopamine receptors and L-type voltage gated calcium channels
- facilitate GABA inhibition

ultimately INCREASE DOPAMINE, NE, and SEROTONIN in brain

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5
Q

buspirone MOA

A

partial agonist at serotonin 5-HT1a

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6
Q

disulfiram

A

blocks dopamine beta hydroxylase in brain

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7
Q

pregabalin

A

calcium channel antagonist

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8
Q

1) baclofen
2) carisoprodol

A

1) GABA-B agonist
2) GABA-A activity (like BZD)

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9
Q

acamprosate

A

antagonist of glutaminergic activity at NMDA receptros

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10
Q

naltrexone

A

mu opioid receptor antagonist

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11
Q

MAOI inhibitor

A

selegine

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12
Q

bupropion

A

block uptake of NE and dopamine, some action on nicotinic and serotonergic receptors

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13
Q

SSRI

A

block serotonin reuptake (5-HT)

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14
Q

mirtazapine

A

antagonism at H1 and alpha -1 receptors

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15
Q

phencyclidine

A

noncompetitive NMDA receptor antagonist; also inhibits reuptake of dopamine, NE, and 5-HT

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16
Q

PCP, ketamine, detromethorphan (DXM), and nitrous oxide (NO)

A

noncompetitive NMDA receptor antagonist
(dissociatives, subclass of hallucinogens)

17
Q

amphetamines & cocaine

A

stimulate release of serotonin & dopamine, and increase circulation of corticotropin-releasing factor (CRF) and nuropeptide Y (NPY) throughout brain regions affecting entire addiction pathway

Addiction Medicine Board Study (12 decks)

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