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Pharmacology > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

This term is defined as frequent or continuous exposure to agonists often results in
short-term diminution of the receptor response.

A

Tachyphylaxis

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2
Q

Drugs that undergo zero order kinetics:

A

WHATPET - Warfarin, Heparin, Aspirin, Tolbutamide, Phenytoin, Ethanol, Theophylline

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3
Q

Drugs than induce cyp450

A

Ethanol, Barbiturates, Phenytoin, Rifampicin, , Griseofulvin, Carbamazepine, St. John’s Wort/Smoking

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4
Q

Ethinyl estradiol, norethindrone, spironolactone, secobarbital, allopurinol, fluroxene, PTU are drugs that bind irreversibly to metabolizing enzymes are called:

A

Suicide inhibitors

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5
Q

Apparent volume of distribution is defined as:

A

Amount of drug in the body/Plasma drug concentration

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6
Q

Clearance is defined as:

A

Rate of elimination/plasma concentration

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7
Q

Corrected dose in renal impairment formula:

A

Average dose x CrCl/100 ml/min

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8
Q

Phase of trial wherein careful evaluation of the dose-response relationship and pharmacokinetics were done among normal human volunteers

A

Phase I

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9
Q

Examples of non selective Direct acting cholinomimetic (muscarinic):

A

Betanechol, Carbachol

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10
Q

Examples of of nm selective Direct acting cholinomimetic (Nicotinic):

A

Succinylcholine

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11
Q

How does Cocaine and TCAs inhibit Norepinephrine metabolism?

A

By inhibiting its reuptake

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12
Q

DOC for Prinzmetal Angina

A

Dilitiazem

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13
Q

Trimetazidine prevents decrease in atp in ischemic states by ihibiting:

A

Beta oxidation of fatty acids

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14
Q

Drug that inhibits Na Current in the SA Node

A

Ivabradine

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15
Q

The most efficacious anti arrythmic drug inhibits which Cardiac Ion channels?

A

Potassium (Class III)

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16
Q

Where do loop diuretics act on the nephron?

A

Thick ascending limb

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17
Q
A
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18
Q

Pyraziniamide can only be used in active phase of tb infection. True or False

A

True

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19
Q

Which is the most hepatotoxic among the first line anti tb drugs?

A

Isoniazide<rifampicin<pyrazinimide

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20
Q

Antifungal that Interferes with microtubule
function. Inhibits synthesis
and polymerization of nucleic
acids. Fungistatic. Identify

A

Griseofulvin

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21
Q

Drug of Choice for Enterococcus

A

Ampicillin +/- Gentamicin

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22
Q

DOC for MSSA

A

Nafcillin

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23
Q

DOC for Penicillin susceptible S. pneumoniae

A

Pen G, Amoxicillin

24
Q

DOC for Penicillin Resistant S. pneumoniae

A

Vancomycin + Ceftriaxone or Cefotaxime +/- Rifampin

25
Q

DOC for C. difficile

A

Metronidazole

26
Q

DOC for C. pneumoniae

A

Erythromycin or tetracycline

27
Q

DOC for C. jejuni

A

Macrolides

28
Q

DOC for Enterobacter

A

Carbapenem, Fluoroquinolone, TMP SMZ

29
Q

DOC for Salmonella

A

Ceftriaxone or Fluoroquinolone

30
Q

DOC for Shigella

A

Fluoroquinolone

31
Q

DOC for P. mirabilis

A

Ampicillin

32
Q

DOC for Serratia

A

Carbapenems

33
Q

Antimicrobial that inhibits protein synthesis but is considered as a bactericidal:

A

Aminoglycosides

34
Q

Drugs causing Disulfiram like reactions:

A

Cefometazole, Metronidazole, Cefamandole, Procarbazine, Cefotetan, Cefoperazone

35
Q

Cefuroxmime, Cefaclor, and Cefoxitine generation?

A

2nd (more of gram negative for Haemophilus, Enterobacter, Neisseria)

36
Q

3rd generation Cephalosporins:

A

Cefoperazone, Ceftriaxone, Cefixime

37
Q

Generation of Cephalosporins that penetrate the BBB

A

3rd (Ceftriaxone)

38
Q

Cephalosporins with hypoprothrombinemia and Disulfiram like reactions:

A

Cefoperazone, Cefotetan, Cefamandole

39
Q

DOC for Gonorrhea given orally

A

Cefixime

40
Q

DOC for Cephalosporin resistant N. gonorrhea

A

Spectinomycin

41
Q

Cephalosporin with very good action in Pseudomonas

A

Ceftazidime

42
Q

All 3rd generation Cephalosporins penetrate the BBB except:

A

Cefoperazone and Ceftazidime

43
Q

4th generation Cephalosporins:

A

Cefepime, Cefpirome, Ceftaroline

44
Q

DOC for Enterobacter, Serratia, and Citrobacter:

A

Carbapenems

45
Q

Inhibits dihydropeptidase 1 that degrades Imipinem

A

Cilastatin

46
Q

Chlorampenicol is bacteriostatic except for the following organisms where its is bactericidal:

A

Neisseria, Haemophilis, Bacteroides, S. pneumoniae

47
Q

What should you not drink when taking up Tetracyclines?

A

Milk

48
Q

Broadest spectrum Tetracycline:

A

Minocycline

49
Q

Drugs for latent TB:

A

Isoniazid and Rifampicin

50
Q

Genes involved in INH resistance:

A

KatG and inhA

51
Q

Preferred DNA dependent RNA polymerase drug for AIDS patients:

A

Rifabutin

52
Q

Sterilizing anti TB drug:

A

Pyrazinamide

53
Q

Second line anti TB that inhibits ATP synthase used for resistance to Isoniazid and Rifampicin:

A

Bedaquiline

54
Q

What drug is added to the RZE regimen in INH resistant Mycobacteria?

A

Levofloxacin

55
Q
A

Pharmacology (8 decks)

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