Pharmacology

Question 1

This term is defined as frequent or continuous exposure to agonists often results in
short-term diminution of the receptor response.

Answer 1

Tachyphylaxis

Question 2

Drugs that undergo zero order kinetics:

Answer 2

WHATPET - Warfarin, Heparin, Aspirin, Tolbutamide, Phenytoin, Ethanol, Theophylline

Question 3

Drugs than induce cyp450

Answer 3

Ethanol, Barbiturates, Phenytoin, Rifampicin, , Griseofulvin, Carbamazepine, St. John’s Wort/Smoking

Question 4

Ethinyl estradiol, norethindrone, spironolactone, secobarbital, allopurinol, fluroxene, PTU are drugs that bind irreversibly to metabolizing enzymes are called:

Answer 4

Suicide inhibitors

Question 5

Apparent volume of distribution is defined as:

Answer 5

Amount of drug in the body/Plasma drug concentration

Question 6

Clearance is defined as:

Answer 6

Rate of elimination/plasma concentration

Question 7

Corrected dose in renal impairment formula:

Answer 7

Average dose x CrCl/100 ml/min

Question 8

Phase of trial wherein careful evaluation of the dose-response relationship and pharmacokinetics were done among normal human volunteers

Answer 8

Phase I

Question 9

Examples of non selective Direct acting cholinomimetic (muscarinic):

Answer 9

Betanechol, Carbachol

Question 10

Examples of of nm selective Direct acting cholinomimetic (Nicotinic):

Answer 10

Succinylcholine

Question 11

How does Cocaine and TCAs inhibit Norepinephrine metabolism?

Answer 11

By inhibiting its reuptake

Question 12

DOC for Prinzmetal Angina

Answer 12

Dilitiazem

Question 13

Trimetazidine prevents decrease in atp in ischemic states by ihibiting:

Answer 13

Beta oxidation of fatty acids

Question 14

Drug that inhibits Na Current in the SA Node

Answer 14

Ivabradine

Question 15

The most efficacious anti arrythmic drug inhibits which Cardiac Ion channels?

Answer 15

Potassium (Class III)

Question 16

Where do loop diuretics act on the nephron?

Answer 16

Thick ascending limb

Question 18

Pyraziniamide can only be used in active phase of tb infection. True or False

Answer 18

True

Question 19

Which is the most hepatotoxic among the first line anti tb drugs?

Answer 19

Isoniazide<rifampicin<pyrazinimide

Question 20

Antifungal that Interferes with microtubule
function. Inhibits synthesis
and polymerization of nucleic
acids. Fungistatic. Identify

Answer 20

Griseofulvin

Question 21

Drug of Choice for Enterococcus

Answer 21

Ampicillin +/- Gentamicin

Question 22

DOC for MSSA

Answer 22

Nafcillin

Question 23

DOC for Penicillin susceptible S. pneumoniae

Answer 23

Pen G, Amoxicillin

Question 24

DOC for Penicillin Resistant S. pneumoniae

Answer 24

Vancomycin + Ceftriaxone or Cefotaxime +/- Rifampin

Question 25

DOC for C. difficile

Answer 25

Metronidazole

Question 26

DOC for C. pneumoniae

Answer 26

Erythromycin or tetracycline

Question 27

DOC for C. jejuni

Answer 27

Macrolides

Question 28

DOC for Enterobacter

Answer 28

Carbapenem, Fluoroquinolone, TMP SMZ

Question 29

DOC for Salmonella

Answer 29

Ceftriaxone or Fluoroquinolone

Question 30

DOC for Shigella

Answer 30

Fluoroquinolone

Question 31

DOC for P. mirabilis

Answer 31

Ampicillin

Question 32

DOC for Serratia

Answer 32

Carbapenems

Question 33

Antimicrobial that inhibits protein synthesis but is considered as a bactericidal:

Answer 33

Aminoglycosides

Question 34

Drugs causing Disulfiram like reactions:

Answer 34

Cefometazole, Metronidazole, Cefamandole, Procarbazine, Cefotetan, Cefoperazone

Question 35

Cefuroxmime, Cefaclor, and Cefoxitine generation?

Answer 35

2nd (more of gram negative for Haemophilus, Enterobacter, Neisseria)

Question 36

3rd generation Cephalosporins:

Answer 36

Cefoperazone, Ceftriaxone, Cefixime

Question 37

Generation of Cephalosporins that penetrate the BBB

Answer 37

3rd (Ceftriaxone)

Question 38

Cephalosporins with hypoprothrombinemia and Disulfiram like reactions:

Answer 38

Cefoperazone, Cefotetan, Cefamandole

Question 39

DOC for Gonorrhea given orally

Answer 39

Cefixime

Question 40

DOC for Cephalosporin resistant N. gonorrhea

Answer 40

Spectinomycin

Question 41

Cephalosporin with very good action in Pseudomonas

Answer 41

Ceftazidime

Question 42

All 3rd generation Cephalosporins penetrate the BBB except:

Answer 42

Cefoperazone and Ceftazidime

Question 43

4th generation Cephalosporins:

Answer 43

Cefepime, Cefpirome, Ceftaroline

Question 44

DOC for Enterobacter, Serratia, and Citrobacter:

Answer 44

Carbapenems

Question 45

Inhibits dihydropeptidase 1 that degrades Imipinem

Answer 45

Cilastatin

Question 46

Chlorampenicol is bacteriostatic except for the following organisms where its is bactericidal:

Answer 46

Neisseria, Haemophilis, Bacteroides, S. pneumoniae

Question 47

What should you not drink when taking up Tetracyclines?

Answer 47

Milk

Question 48

Broadest spectrum Tetracycline:

Answer 48

Minocycline

Question 49

Drugs for latent TB:

Answer 49

Isoniazid and Rifampicin

Question 50

Genes involved in INH resistance:

Answer 50

KatG and inhA

Question 51

Preferred DNA dependent RNA polymerase drug for AIDS patients:

Answer 51

Rifabutin

Question 52

Sterilizing anti TB drug:

Answer 52

Pyrazinamide

Question 53

Second line anti TB that inhibits ATP synthase used for resistance to Isoniazid and Rifampicin:

Answer 53

Bedaquiline

Question 54

What drug is added to the RZE regimen in INH resistant Mycobacteria?

Answer 54

Levofloxacin