pharmacology Flashcards
what is the role of the autonomic nervous system
mediates output from the CNS to the whole body
describe the basic organisation of the motor ANS
2 motor neurones in series: preganglionic and postganglionic
neurotransmitter in preganglionic neurones
acetylcholine
neurotransmitter in postganglionic sympathetic neurones
noradrenaline
neurotransmitter in postganglionic parasympathetic neurones
acetylcholine
where do preganglionic neurones originate in the sympathetic division of the ANS
thoracolumbar region
what is the role of the sympathetic ANS
fight or flight
what are nicotinic acetylcholine receptors
ligand-gated ion channels activated by acetylcholine, involved in cholinergic transmission
what are muscarinic cholinoceptors
G-protein coupled receptors activated by acetylcholine in parasympathetic transmission.
what are adrenoceptors
G-protein coupled receptors activated by adrenaline/noradrenaline
name the 2 main classes of adrenoceptors
alpha and beta
what are b1 adrenoceptors coupled with
Gs
what are b2 adrenoceptors coupled with
Gs
what are a1 adrenoceptors coupled with
Gq
what are a2 adrenoceptors coupled with
Gi
role of b1 adrenoceptors
increase heart rate and force of contraction
role of b2 adrenoceptors
relaxation of bronchial and vascular smooth muscle
role of a1 adrenoceptors
contraction of vascular smooth muscle
role of a2 adrenoceptors
inhibition of NA release
where do parasympathetic preganglionic neurones originate
craniosacral region
which kind of receptors is the parasympathetic ANS stimulated by
muscarinic cholinoceptors
what are M1 receptors coupled with
Gq
what are M2 receptors coupled with
Gi
what are M3 receptors coupled with
Gq
