PHARMACOLOGY

Question 1

is the area of pharmacology concerned with the use of chemicals in the prevention, diagnosis, and treatment of disease, especially in humans

Answer 1

Medical Pharmacology

Question 2

Drugs are chemicals that modify body functions. They may be ions, carbohydrates, lipids, or proteins.
They vary in size from LITHIUM (MW 7) to PROTEINS (MW 50,000)

Answer 2

Nature of drugs

Question 3

MOA of Bevacizumab

Answer 3

for cancer; inhibit VRGF (vascular endothelial growth factor) - vascularization

Question 4

Causes of Vit B12 deficiency:

Answer 4

a. Chronic use of Proton pump Inhibitor
b. H2 Blockers
c. Diphylobotrium latum (fish tapeworm): competes in Vit B12 absorption

Question 5

Diagnostic agent for Myasthenia gravis

Answer 5

Edrophonium (Tensilon)

Question 6

Used in pulmonary challenge test

Answer 6

Histamine

Question 7

Radiopaque; to visualize the outline of the GIT

Answer 7

Barium Sulfate

Question 8

Class III antiarrhythmic (Aminodarone) are blockers of what ion?

Answer 8

K

Question 9

aka Kininase

Answer 9

ACEI

Question 10

a factor that will determine the number of drug-receptor complexes formed.

Answer 10

Receptor affinity of the drug

Question 11

A molecule to which a drug may bind without changing any function

Answer 11

Inert binding molecule or site

Question 12

Receptor that does not bind drug when the drug concentration is sufficient to produce maximal effect; present when Kd > EC50

Answer 12

Spare receptor

Question 13

Component of a system that accomplishes the biologic effect after the receptor is activated by an agonist; often a channel or enzyme molecule

Answer 13

Effector

Question 14

Trimethapan
Mecamylamine
Hexamethoprim

Answer 14

Ganglionic blockers, Nn

Question 15

Succinylcholine

Answer 15

Neuromuscular blockers, Nm

Question 16

Enzyme-linked receptors

Answer 16

Type III

Question 17

translocation of glucose transportation

Answer 17

Type III

Question 18

Involved in the action of NO

Answer 18

Type III

Question 19

Atrial natiuretic peptide receptor

Answer 19

Type III

Question 20

This distinguishes receptor-drug interaction from enzyme-substrate interaction

Answer 20

Reversibility

Question 21

The drug should bind to receptors then dissociate in its non-metabolized form

Answer 21

Reversibility

Question 22

PARTIAL AGONIST have a _ intrinsic activity than full agonist; however their affinity for the receptor can be greater than, or less than, or equal to that of full agonist.

Answer 22

LOWER intrinsic activity

Question 23

a drug that inhibits baseline level of activity, in the absence of agonist

Answer 23

Inverse agonist

Question 24

a ligand which produces an effect opposite to that of an agonist occupying the same receptor

Answer 24

Inverse agonist