Pharmacology

Question 1

First-order pharmacokinetics

Answer 1

Linear process
Constant fraction of drug eliminated per unit of time

Question 2

Pharmacokinetic parameter that contributes to neonates needing a higher dose of gentamicin compared to older infants/children.

Answer 2

Distribution

Infants have higher percentage of TBW and higher ratio of water to lipid in adipose tissue.

Question 3

Lipidemia
Fever
Hepatomegaly
Rhabdomyolysis
Hyperkalemia
ECG change (ie Brugada)

Answer 3

Propofol infusion syndrome

Question 4

Elimination of cisatracurium

Answer 4

Biodegraded by Hofmann elimination, a pH dependent chemical degradation with the formation of laundanosine and a monoquarternary alcohol

Question 5

Sufammadex dosing for paralytic reversal

Answer 5

16 mg/kg

Question 6

Half-life of Dexmedetomidine

Answer 6

2 hours

Question 7

Levothyroxine IV to PO dose

Answer 7

50% reduction from IV to PO

Question 8

Hyperthermia
Muscle rigidity
Rhabdomyolysis
Acidosis
Hypertension
AMS

Answer 8

Neuroleptic Malignant Syndrome

Question 9

Adverse effects of pentobarbital

Answer 9

Propylene glycol toxicity
-lactic acidosis
-hypotension
-AKI

Question 10

Drug that completely inhibits the activation of plasminogen to plasmin

Answer 10

Epsilon-amionocaproic acid

Question 11

Electrolyte abnormalities with Tacrolimus

Answer 11

Hypomagnesemia
Hypocalcemia