Pharmacokinetics - Kahoot Quiz Flashcards
The BIOAVAILABILITY of a drug is the fraction of an oral dose which ….?
Reaches the systemic circulation
Which route is most suitable to deliver glyceryl trinitrate to relieve acute anginal pain
Buccal Delivery Under the Tongue
For a child exhibiting epileptic seizures, which route is most suitable for medication delivery?
- Rectal Route using suppositories
Which of the following best explains the term PRODRUG ?
- A drug that enhances performance in sport
- A drug activated by liver metbolism
- A drug activated as its target site of action
- A drug that is not absorbed by the gastrintestinal tract
- A drug activated by liver metabolism
The binding of a drug to plasma protein
- Decreases its oral absoprtion
- Enhances its duration of action
- Enhances its excretion by the kidneys
- Reduces its duration of action
Enhances its duration of action
Which property of a drug is most important for it to cross the blood-brain barrier?
- Lipid solubility
Which property of morphine is essential for its ability to cross the blood-brain barrier?
- Weak acid
- Weak Base
- Substrtae for active transport
- Convertion to the lipid soluble diamorphine
Weak base
Which of the following options best describes PHASE 1 drug metabolism
- Drug inactivation by the liver
- Drug conjugation in the kidney
- Drug Inactivation by the GI tract
- Drug conjugation in the liver
Drug inactivation by the liver
What is phase II drug metabilsm
- Production of water-soluble metabolites
How does a kidney handle lipid-soluble drugs compared to a water-soluble drug ?
- Reduced glomerular filtration
- Passive reabsoption
- Enhanced renal secretion
- Enhanced glomerular filtration
- Passive reabsoption
What happens to a drug excreted enhanced in urine in a patient with reduced renal function?
- Reduced plama concentration
- Retension in kidney tissue
- Increased plasma concentration
- Enhanced protein binding
- Increased plasma concentration
Why is codeine ineffective as an analgesic for 1 in 10 Caucasian population ?
- Lack of oral absoprtion
- Genetic polymorphism
- Lack of appropriate opiate receptors
- Extensive protein binding
Genetic polymorphism
What will a liver enzyme inhibitor do to a drug which is a substrate for hepatic metabolism ?
Increase its plasma concentration
What will a liver enzyme inducer do to a drug with a substrate for hepatic metabolism ?
- Reducing its plasma concentration
