Cytotoxic Chemotherapy Flashcards
Why is combination therapy useful in chemotherapy?
Combination drug chemotherapy is more successful than single-drug treatment in most of the cancers for which chemotherapy is effective
- Different cellular mechanism of action
- Different cell cycle specificity
What does “major dose limiting” adverse effects mean ?
Cytotoxic agents with same toxicities can only be combined by reducing the doses of each
Cytotoxic agents with different toxicities and different mechanisms combined at full doses
Adverse effects minimised by cytoprotectant drugs ie folinic acid with methotrexate
What type of cancer is an example of the use of drug combinations in cancer ?
The drugs for non-Hodgkins lymphoma
What is non-Hodgkins lymphoma ?
Non-Hodgkin lymphoma (NHL) is a type of blood cancer that affects white blood cells called lymphocytes. It is also called a cancer of the lymphatic system.
What is the treatment for non-hodgkin lymphoma?
What are the symptoms of non-hodkins lymphoma ?
The most common symptom of NHL is one or more painless swellings in the neck, armpit or groin.
How is R-CHOP administered?
