Pharmacokinetics and Pharmacodynamics Flashcards
deals with drug’s actions as it moves through the body; discusses how drug is
Pharmacokinetics
covers a drug’s progress from the time it’s administered, through its passage to the tissues, until it reaches systemic circulation.
Drug absorption
On a cellular level, drugs are absorbed by several means—primarily through?
Active or passive transport
is the process by which the drug is delivered from the systemic circulation to body tissues and fluids.
Distribution
Factors affecting drug distribution?
Blood flow
Solubility
Protein Binding
is the process by which the body changes a drug from its dosage form to a more water-soluble form that can then be excreted.
Metabolism or Biontransformation
Drugs are metabolized into?
Active and Inactive metabolites
Are metabolites which are then excreted?A
Inactive metabolites
Metabolites that undergo further metabolism and may be excreted unchanged?
Active metabolites
refers to the elimination of drugs from the body
Excretion
Routes for drug excretion
kidneys, lungs, exocrine glands, skin, intestinal tract
Pharmacokinetics is a branch of pharmacology is also concerned with?
Drug’s onset of action
Peak concentration level
Duration of action
The study of the drug mechanisms that produce biochemical or physiologic changes in the body. The interaction at the cellular level between a drug and cellular components, such as the complex proteins that make up the cell membrane, enzymes, or target receptors, represents drug action. The response resulting from this drug action is the drug effect.
Pharmacodynamics
It is the response resulting from the drug action
drug effect
The use of drugs to treat disease
Pharmacotherapeutics
