Pharmacokinetics

Question 1

Pharmacokinetics is ..

Answer 1

what the body does to a drug (drug movement into and throughout the body)

Question 2

Invasion

Answer 2

active substance is freed from dosage form, absorption from administration site, distribution into human body

Question 3

Elimination

Answer 3

Metabolism (biotransformation), excretion of drugs

Question 4

Absorption depends on

Answer 4

the drug’s physicochemical properties, the formulation, the route of administration.

Question 5

Passive diffusion

Answer 5

high to low concentration (cannot go against it), no energy, rate depends on gradient, solubility (lipids more rapid), size (smaller more rapid), ionization (unpolarized more easily), area of absorption (small intestine large area)

Question 6

Facilitated diffusion

Answer 6

drug combines with some carrier molecules, no energy, can go against, only for similar to endogenous substances.

Question 7

Pinocytosis

Answer 7

membrane invaginate, encloses fluid or particles, form vesicle in interior, requires energy

Question 8

Active transport

Answer 8

needs carriers, does require energy, transport against gradient, specific only for drugs structurally similar to endogenous.