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Pharmacology > Cholinergic Drugs > Flashcards

Cholinergic Drugs Flashcards

1
Q

Direct acting (stimulates muscarinic or nicotinic receptors)- CHOLINE ESTERS

A

acetylcholine (Ach), carbachol (all must some Nic), metacoline (all musc), bethanecol (m3)

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2
Q

Direct acting - NATURAL ALKALOIDS

A

pilocarpine, arecoline, muscarine, nicotine

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3
Q

Indirect acting - REVERSIBLE CHOLINESTERASE INHIBITORS

A

Neostigmine, physostigmine, pyridostigmine, ephronium, donepezil

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4
Q

Indirect acting - IRREVERSIBLE CHOLINESTERASE INHIBITORS (organophosphate compounds)

A

Ecothiophate, isoflurophate, malathion

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5
Q

Direct cholinergic agonists

A

directly stimulate cholinergic receptors and produce characteristic effects

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6
Q

Carbachol mechanism

A

both nicotinic and muscarinic, biotransformed by esterases @ slower rate compared to Ach, strong action on GI, urinary, eye

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7
Q

Carbachol indications

A

glaucoma (limited, local, high potency, long duration of action), strimulation of postoperative urinary bladder, atonic intestinal smooth muscle

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8
Q

Carbachol Se

A

gastric acid hypersecretion

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9
Q

Carbachol preparation

A

Miostat ophthalmic sol.

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10
Q

Metacholine mechanism

A

Cardiovascular system

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11
Q

Metacholine indications

A

Raynaud, paroxystic tachycardia

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12
Q

Bethanecol mechanism

A

strong muscarinic and little/no nicotinic, acts on sm musc of bladder and GI tract (one hour actioN)

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13
Q

Betanecol indications

A

atonic bladder, atonic intestinal smooth muscle

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14
Q

Bethanecol SE

A

salivation, abdominal pain, diarrhea, sweating, low blood pressure

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15
Q

Pilocarpine chemistry

A

alkaloid from leaves of pilocarpine jaborandi

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16
Q

Pilocarpine PD/Mechanism

A

muscarinic, rapid myosis (contact ciliary muscle), increases acqueous humor drainage which lowers ICP, stimulates sweat, saliva, tears

17
Q

Pilocarpine indications

A

glaucoma, iritis, idido-capsulitis, litiais sof salivary glands, intoxication of atropine

Pharmacology (12 decks)

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