pharmacokinetics

Question 1

name 4 methods of absorption

Answer 1

internal
topical
inhalation
injection

Question 2

define volume distribution

Answer 2

the apparent volume that the the total mount of drug appears to have distributed based on initial plasma concentration

Question 3

name 4 factors that effect drug distribution

Answer 3

protein binding
lipid solubility
blood flow
ionisation

Question 4

what is phase 1 of drug metabolism

Answer 4

non synthetic, non selective detoxification- activates the drug

Question 5

what is phase 2 of drug metabolism

Answer 5

synthetic, adds a substitute group to deactivate

Question 6

name 4 ways of which a drug can be expelled

Answer 6

renal excretion
billary excretion
breast milk
expired air

Question 7

what is drug clearance

Answer 7

the volume of plasma cleared of drug by metabolism or excretion per unit of time

Question 8

what is the clearance of a first order drug

Answer 8

constant fraction cleared per unit of time- proportional to concentration

Question 9

what is the clearance of a zero order drug

Answer 9

constant rate of elimination regardless of plasma concentration- proportional to time