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Nervous system > pharmacodynamics > Flashcards

pharmacodynamics Flashcards

1
Q

what is pharmacodynamics

A

action of drugs in the body

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2
Q

what is drug specificity

A

how a drug selectively binds to a particular protein

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3
Q

what is drug affinity

A

how well a drug binds

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4
Q

what is drug efficacy

A

how well a drug brings about a response

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5
Q

describe the action of drugs that target ligand gated ion channels

A

change ionic movement across cell membrane

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6
Q

describe the action of drugs that target G protein coupled receptors

A

bind to transmembrane G protein receptor, changing physiological processes

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7
Q

what is the action of GαS in G protein coupled receptors

A

stimulates conversion of ATP to cAMP

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8
Q

what is the action of GαI in G protein coupled receptors

A

inhibits conversion of ATP to cAMP

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9
Q

what is the action of Gαq in G protein coupled receptors

A

activates conversion of PIP2 to DAG and IP3

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10
Q

describe the action of drugs that target kinase linked receptors

A

will bind to a transmembrane receptor, blocking chemical messengers an therefore changing protein synthesis inside the cell

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11
Q

what is cAMP and its role

A

Cyclic adenosine monophosphate

it is a cellular messenger

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12
Q

describe the action of drugs that target nuclear receptors

A

act in the nucleus, changing gene transcription

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13
Q

what is the action of agonist drugs

A

activate cell receptor sites- they form a drug receptor complex which becomes activated

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14
Q

what 2 factors are considered when working out potency of an agonist drug

A

affinity (how well it binds)
efficacy (how well a response is brought about)

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15
Q

what is the action of antagonist drugs

A

block receptor sites on a cell- they bind to site and deactivate the cell

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16
Q

how would you measure effectiveness of an antagonist drug

A

compare effect on cell with against only and with antagonist only

right had shift indicates effectiveness

17
Q

name 4 factors that could influence the effectiveness of a drug on the body

A

age
gender
disease
weight

18
Q

describe drug desensitisation

A

reduced response of a receptor to a drug, reducing effectiveness (result of a long term dosage)

19
Q

describe drug tolerance

A

body gets used to medication do there is reduces effect

20
Q

describe drug resistance

A

adaptive change that makes drug less effective, microorganism is no longer killed

Nervous system (13 decks)

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