cell to cell communication Flashcards
describe endocrine cell signalling
hormones secreted into bloodstream, and travel to distant cells/organs
describe paracrine cell signalling
cells secrete hormone which is distributed locally
describe synaptic cell signalling
neurotransmitter released into synapse to carry electrical signal from one cell to another
describe ion gated cell signalling
receptor on ion gated channel, when a ligand bind it will cause a change in structure of channel
what conditions are associated with damage to ion gated cell signalling
epilepsy
cardiac dysfunction
describe G-protein coupled cell signalling
transmembrane receptor, ligand bind to outside, causing the inside component of receptor to bind to GTP, converting it to GDP and causing cellular change
describe enzyme linked cell signalling
ligand binds to 2 adjacent receptors, they phosphorylate eachother creating reaction cascade which will eventually be terminated by signalling GTP proteins or protein phosphorylsation
describe the 2 types of contact cell signalling
gap auctions between 2 connected cells
signalling molecule of cell surface of one cell, relying on contact with receptor on cell surface of another cell
what condition would be associated with damage to enzyme linked cell signalling
cancer- no RAS to stop cell signalling, constant reproduction
what condition is associated with damage to production of G proteins in G protein coupled receptor cell signalling
pseudohyploparathyroidism
what condition is associated with reduced signal initiation in G protein coupled receptor cell signalling
whooping cough
what condition is associated with increased signal initiation in G protein coupled receptor cell signalling
hypertension