Pharmacokinetics Flashcards
Which route is most suitable to deliver glyceryl trinitrate to relieve acute anginal pain?
Buccal delivery under the tongue
For a child with epileptic seizures, what is most suitable route for medication delivery
Rectal route using suppositories
The bioavailability of a drug is the fraction of an oral dose which?????
Reaches the systemic circulation
What is a Prodrug??
A drug activated by Liver metabolism
The binding of a drug to plasma protein……….
Enhances its duration of action
What property of a drug is most important to allow crossing of the blood/brain barrier?
Lipid Solubility
Which property of morphine is most important for its ability to cross the blood/brain barrier?
It is a Weak base
What is PHASE 1drug metabolism???
Inactivation the drug by the Liver
What is PHASE 2 drug metabolism???
Production of water soluble metabolites
How does the kidney handle lipid soluble drugs compared to water soluble drugs??
Passive Reabsorption-
(Lipids/un-ionised
undergo passive reabsorption into blood; Water/ionised drugs retained in tubule.)
What happens to a drug excreted unchanged in Urine, in patients with reduced kidney function??
Increased plasma concentration
Why is codeine ineffective analgesia for 1/10 of Caucasians??
Genetic Polymorphism
What will Liver enzyme inhibitor do to drug which is substrate for hepatic metabolism??
Increase its plasma concentration-
Substrates= drugs that bind to active site of enzyme and transformed into metabolites whilst present on active site
Decreased metabolism of drug by liver
What will liver enzyme inducer do to drug that is a substrate for hepatic metabolism???
Reduce its plasma concentration-
Substrates= drugs that bind to active site of enzyme and transformed into metabolites whilst present on active site
Increased metabolism of drug by live
