NSAIDs

Question 1

What drug is an irreversible inhibitor of the COX enzyme???

Answer 1

Aspirin

Question 2

Name two NSAIDs

Answer 2

Naproxen
Ibuprofen

Question 3

What drug is an selective inhibitor of the COX-2 ???

Answer 3

Celecoxib

Question 4

What drug is known to reduce the risk of Thrombotic events??

Answer 4

Aspirin

Question 5

Hepatoxicity is a life threatening event in acute overdose of which drug??

Answer 5

Paracetamol

Question 6

What pharmacological property of aspirin results in inhibition of platelet aggregation??

Answer 6

irreversible inhibitor of the COX enzyme

Question 7

The hepatotoxic effect of paracetamol is due to saturation of which mechanism??

Answer 7

Phase 2 Conjugation to Glutathione
Glutathione is toxic metabolite, Liver has limited capacity to excrete

Question 8

What is the maximum dose of IV Paracetamol in adults weighing less than 50kg??

Answer 8

60mg/kg

Question 9

What is a common iatrogenic property of NSAIDs??

Answer 9

Ulceration of GI tract