Pharmacokinetics

Question 1

a compilation of herbal remedies, compiled during the reign of Shennung

Answer 1

Pen Tsao

Question 2

Composed of over 800 prescriptions for salves, platers, pills, suppositories, and other dosage forms used to treat specific ailments

Answer 2

Ebers Payrus

Question 3

a compilation of therapeutic substances and their uses

Answer 3

Materia Medica (first and true)

Question 4

a veterinary compilation for farm animal treatments, compiled by scholars in Byzantium

Answer 4

Publius Vegitius

Question 5

Official compilations of medicinal substances, their preparation, use, and dosages. started in Europe

Answer 5

Pharmacopeia

Question 6

First printed pharmacopeia

Answer 6

Dispensatorium

Question 7

Most influential compilation of drugs during renaissance

Answer 7

Edinburgh Pharmacopeia

Question 8

father of medicine

Answer 8

Hippocrates

Question 9

compiled the first true materia medica

Answer 9

Dioscorides

Question 10

Introduced the clinical use of laudanum (opium) and a number of tinctures (extracts) of various plants. coined the phrase “All substances are poisons; there is none which is not. The proper dose separates a poison from a remedy.”

Answer 10

Phillipus Aureolus Theophrastus Bombastus von Hohenheim / Paracelcus

Question 11

compiled the first printed pharmacopeia in 1547 in Nuremburg, Germany

Answer 11

Sir Christopher Wren

Question 12

Reported on his experience in the use of extracts from the foxglove plant to treat patients with “dropsy” a form off edema most likely caused by congestive heart failure

Answer 12

William Withering

Question 13

Studied the effects of iv injections of ipecac, morphine, etc on animals. first to prove that chemicals can be absorbed into the vascular system to exert a systemic effect

Answer 13

Megendie

Question 14

Showed in mid 1800s that the active ingredient of foxglove botanical preparation ma was digitalis, and its action was on the heart

Answer 14

Claude Bernard

Question 15

Ranks drugs acc to the extent and rate of absorption

Answer 15

Biopharmaceutical Classification System

Question 16

May be absorbed by active transport systems in the small intestine

Answer 16

Beta lactams

Question 17

Expels absorbed drug back into the intestinal lumen of the intestines

Answer 17

P-glycoprotein transport systems

Question 18

Most important mechanism in drug hepatic elimination

Answer 18

The biliary excretion process

Question 19

Dyes used as diagnostic probes of liver function and model substances in the studies of the hepatic uptake of organic anions

Answer 19

Bromosulfophtalein and analogues

Question 20

actively excreted into the bile in the presence of biliary tract obstruction

Answer 20

Ciprofloxacin

Question 21

mainly excreted into the small intestine via glomerular filtration and also concentrated in the liver and accordingly excreted into the small intestine via the bile and then partially reabsored

Answer 21

Tetracyclines

Question 22

an endogenous compound actively transported from hepatocytes into bile via transport systems similar to those for organic anions

Answer 22

Glucuronides