Pharmacokinetic Drug-drug interactions (Excretion) Flashcards

1
Q

Aspirin + Urinary alkalinizer
Barbs, NSAIDs, Amphetamine + Urinary modification

A

Alteration of pH

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2
Q

Penicillin + Probenecid
NSAIDs + Lithium

A

Alteration of active transport

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3
Q

Digoxin + Quinidine
Alteration of…

A

Alteration of drug transport

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3
Q

Aspirin + Urinary alkalinizer

A

Acid + Polar/Ionized = excreted

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4
Q

Barbs, NSAIDs, Amphetamine + Urinary modification

A

Excreted

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5
Q

Penicillin + Probenecid

A

Probenecid blocks active tubular secretion of penicillin

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6
Q

NSAIDs + Lithium

A

NSAIDs inhibit renal Li excretion

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7
Q

Digoxin + Quinidine

A

Quinidine inhibits renal excretion of digoxin

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