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AREA 3 -DISPENSING AND INCOMPATIBILITIES > Pharmacokinetic Drug-drug interactions (Absorption) > Flashcards

Pharmacokinetic Drug-drug interactions (Absorption) Flashcards

1
Q

Antacid +

A

Ketoconazole
Bisacodyl

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2
Q

Antibiotics +

A

Warfarin
Digoxin
OCPs

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3
Q

Tetracycline/Fluoroquinolones +

A

Metal-containing products

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4
Q

Cholestyramine/Colestipol +

A

Fat-soluble drugs

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5
Q

Deferoxamine +

A

Fe

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6
Q

Use of antibiotics

A

Alteration of GI flora

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7
Q

Tetracycline/Fluoroquinolones + Metal-containing products
Cholestyramine/Colestipol + Fat-soluble drugs
Deferoxamine + Fe

A

Complexation/Adsorption

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8
Q

Ketoconazole + Antacid

A

Weak base + Basic environment = decrease absorption

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9
Q

Bisacodyl + Antacid

A

Enteric coated + Basic environment = Unionized = increase chance of systemic absorption = decrease effect in colonic nerves

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10
Q

Antibiotics + Warfarin

A

Increase warfarin effect

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11
Q

Antibiotics + Digoxin

A

Increase digoxin toxicity

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12
Q

Antibiotics + OCPs

A

Increase chances of unwanted pregnancy

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13
Q

Tetracycline/Fluoroquinolones + Metal-containing products

A

Decrease antibiotic effect

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14
Q

Cholestyramine/Colestipol + Fat-soluble drugs

A

Decrease absorption of fat-soluble drugs

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15
Q

Fat-soluble drugs

A

Vitamin ADEK
Digoxin
Warfarin
Thyroid hormones

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AREA 3 -DISPENSING AND INCOMPATIBILITIES (32 decks)

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