Pharmacogenomics

Question 1

Testing for HLA-B*5701 is done for which drug?

Answer 1

Abacavir
Fatal hypersensitivity reactions can occur
If positive, do not use

Question 2

Testing for HLA-B*5801 is done for which drug?

Answer 2

Allopurinol
Increased risk of SJS
Discontinue at first sign of allergic reaction
If positive, do not use

Question 3

Testing for HLA-B*1502 is done for which drugs? (4 drugs)

Answer 3

Carbamazepine, oxcarbazepine, phenytoin, fosphenytoin
Increased risk of SJS and TEN
Test all Asian patients before starting carbamazepine
If positive, do not use

Question 4

Key drugs with pharmacogenomic implications and require/strongly recommend testing (5 drugs)

Answer 4

Abacavir and any combo products containing abacavir
Azathioprine
Carbamazepine
Cetuximab and other EGFR inhibitors
Trastuzumab and other HER2 inhibitors