Pharmacogenomics Flashcards
Pharmacogenetics
altered drug response in an individual linked to a genetic cause
Pharmacogenomics
altered drug response in a population linked to a genetic cause
Allele
alternative form of a gene
Genetics can cause what type of differences?
metabolism of the drug
alteration of the drug target
absorption of the drug
single nucleotide polymorphism (SNP)
alteration of 1 nucleotide
can cause altered function
SNP in coding region
changes the amino acid encoded
SNP in intron
alters the promotor/splicing
Variable number tandem repeats (VNTR)
repeating strings of nucleotides that can alter function
usually 4-40
True positive
has an alteration and identifies as alteration
true negative
has no alteration and identifies as no alteration
false positive
identifies as alteration when not
false negative
identifies as no alteration when is
what is the effect of a false positive in an efficacy study?
disease is untreated
what is the effect of a false negative in an efficacy study
think drug wont work but it would have
end up treating with different drug
what is the effect of a false positive in a safety study
think a complication will occur when it wont