DNA Metabolism Part 2 Flashcards
1
Q
Is damage to RNA and proteins major?
A
no
2
Q
Where can DNA damage come from?
A
- chemical agents
- environmental factors
- errors during replication
3
Q
Lesion
A
unrepaired DNA damage
4
Q
substitution mutation
A
switch bases
5
Q
insertion mutation
A
add extra nucleotide
6
Q
deletion mutation
A
skip/miss a nucleotide
7
Q
silent mutation
A
mutations in non essential DNA or with no effect on gene function
8
Q
most mutations are?
A
neutral or deleterious
9
Q
What does an accumulation of mutations correlate with?
A
cancer
10
Q
What percentage of compounds shown to cause cancer are mutagenic?
A
90%
11
Q
Because of repair mechanisms less than x in 1000 become mutations?
A
1
12
Q
Is DNA repair energetically efficient?
A
yes
13
Q
DNA Repair Systems
A
mismatch
base excision
nucleotide
direct
14
Q
Mut L/ Mut S complex
A
looks for a mismatch in mismatch repair
15
Q
Mut H
A
cuts the new strand in mismatch repair
