Pharmacogenetics

Question 1

Pharmacokinetics

Answer 1

what the body does to the drug

Question 2

Pharmacodynamics

Answer 2

What the drug does to the body

Question 3

What is the role of TPMT (Thiopurine methyltransferase)

Answer 3

TPMT is an enzyme that inactivates certain drugs

Question 4

What is the role of N-acetyltransferase activity?

Answer 4

N-acetyltransferases are a group of liver enzymes inactivating drugs by acetylation.

Question 5

What is succinylcholine used for?

Answer 5

Muscle relaxant used in anaesthesia to stop breathing. Artificial ventilation vital.

Question 6

How does aminoglycoside induced hearing loss occur?

Answer 6

A mutation in the structure of the rRNA makes it more likeley for aminoglycosides to bind. This increases risk of hearing loss at a younger age.

Mitochondria encode for these 12s rRNA so the condition has meternal inheritance.

Question 7

When should trastuzumab (herceptin) be used to treat breast cancer?

Answer 7

When the HER2 receptor is overexpressed, patients benefit from trastuzumab (herceptin).

It is a monoclonal antibody that binds to the HER2 receptor and blocks it.

Question 8

In what gene does 50% of melanomas have a somatic mutation in?

Answer 8

BRAF