Familial Cancer Flashcards
What do caretaker genes control?
- DNA repar
- carcinogen metabolism
What do gatekeep genes do?
Controll cell cycle and programmed cell death
what is penetrance?
The percentage of people with the mutated gene who develop the condition
what is the function of the cancer gene?
They are gatekeepers so work to monitor and control cell division and death.
caretakers - repair DNA.
Landscapers - control the surrounding stromal environment.
What is the role of the tumour suppressor gene?
protects cells from becoming cancerous
What is the role of oncogenes?
regulate cell growth and differentiation
What inheritance pattern do most cancer syndromes show?
Autosomal dominant inheritance pattern
What type of cancer follows Knudson 2 hit hypothesis?
Retinoblastoma
What does FAP stand for?
Familial Adenomatous Polyposis
What should be excluded in the amsterdam criteria for HNPCC (hereditary Non-Polyposis Colorectal Cancer)
FAP (familal adenomatous polyposis)
What are BRCA1&2 genes normally for
DNA repair
How is the mutated BRCA 1 & 2 inherited?
Autosomal Dominant
What mutation occurs in Li Fraumeni Syndrome?
P53 mutation
How is Li Fraumeni Syndrome inherited?
Autosomal dominant
What has a higher risk of becoming cancerous in Li Fraumeni Syndrome?
Breast Brain Sarcoma Adrenocorticak Leukaemia
