pharmacogenetics Flashcards
1
Q
what’s the most common type of variation in the genome?
A
SNPs
2
Q
snp scoring
A
correlation of SNPs to clinical phenotype
3
Q
If patient has c-erbB1 ( EGFR) what does that increase risk of?
A
brain tumors and worse prognosis
4
Q
If patient has BRCA1/2 what does that increase risk of?
A
breast cancer
5
Q
what enzymes metabolize 40% of all drugs ?
A
CYP2C9
CYP2D6
CYP2C19
6
Q
what does SNPs in CYP2C9 CYP2D6 CYP2C19 result in ?
A
classification of patients into poor vs extensive metabolizers
