antineoplastics

Question 1

what are the cell cycle nonspecific drugs?

Answer 1

alkylating agents 
antibiotics 
nitrosureas
cisplatin 
antibodies

Question 2

alkylating agents aka

Answer 2

warfare or nitrogen mustards

Question 3

Moa of alkylating agents

Answer 3

make carbonium which transfers its alkyl group to guanine on position 7 and prevents formation of imp metabolites that leads to halt in dna rep and the cell dies

Question 4

antimetabolites moa

Answer 4

s phase specific drugs that are structural analogues of imp metabolites and that way interfere dna/rna/protein formation

Question 5

antibiotics moa

Answer 5

intercalate btwn bps –> topoismoerase ii inhibited and free radicals fare formed –> inhibition of. dna synthesis and cause strand incision

Question 6

alkaloid moa

Answer 6

bind to tubulin –> inhibit mitotic filament formation –> arrest in G2/ M phase

Question 7

platinum compounds Moa

Answer 7

bind to guanine in dna –> stabilized by H bonds –> shortening / unwinding of helix

Question 8

hormone dependent cancers respond to ..

Answer 8

hormone antagonists