geriatric pharma Flashcards
<21
paedatric
> 65
geriatric
<1 month
neonates
1m - 2 years
infants
2 yrs - 12 yrs
child
12-21 years
adolescent
what 4 things does drug absoprtion depend on?
blood flow at site of action
rectal absorption
transdermal absorption
GI function
what may cause cv shock and vasoconstriction in neonates?
anticonvulsants
sympathomimetic agents
antibiotics
higher membrane permeability (BBB) may result in what?
kernicterus aka brain damage
what do glucocorticoids do?
affect growth and development bc they cause early fusion of epiphysis
how to calculate dose based on age
adult dose x age / age + 12
how to calculate dose based on weight
adult dose x weight / ( 70 if kg and 150 if lbs)
how to calculate dose based on surface area ( most accurate)
adult dose x SA of child in m^2 / 1.7
Cockcroft Gault formula ( age 40-80)
creatinine clearance ( ml/min) = (140-age) x weight in kg / 72 x serum, creatinine in mg/dL
for women x 0.85. ( bc reduced. muscle mass)
in elderly there is a decrease in response of what receptor agonists>?
beta adrenoceptor agonists