geriatric pharma Flashcards

1
Q

<21

A

paedatric

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2
Q

> 65

A

geriatric

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3
Q

<1 month

A

neonates

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4
Q

1m - 2 years

A

infants

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5
Q

2 yrs - 12 yrs

A

child

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6
Q

12-21 years

A

adolescent

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7
Q

what 4 things does drug absoprtion depend on?

A

blood flow at site of action
rectal absorption
transdermal absorption
GI function

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8
Q

what may cause cv shock and vasoconstriction in neonates?

A

anticonvulsants
sympathomimetic agents
antibiotics

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9
Q

higher membrane permeability (BBB) may result in what?

A

kernicterus aka brain damage

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10
Q

what do glucocorticoids do?

A

affect growth and development bc they cause early fusion of epiphysis

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11
Q

how to calculate dose based on age

A

adult dose x age / age + 12

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12
Q

how to calculate dose based on weight

A

adult dose x weight / ( 70 if kg and 150 if lbs)

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13
Q

how to calculate dose based on surface area ( most accurate)

A

adult dose x SA of child in m^2 / 1.7

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14
Q

Cockcroft Gault formula ( age 40-80)

A

creatinine clearance ( ml/min) = (140-age) x weight in kg / 72 x serum, creatinine in mg/dL

for women x 0.85. ( bc reduced. muscle mass)

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15
Q

in elderly there is a decrease in response of what receptor agonists>?

A

beta adrenoceptor agonists

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16
Q

what is less effective in old people

A

b1 agonists

17
Q

what are olde people more sensitive to ?

A

cns depressants