Pharmacogenetics

Question 0

CYP2D6 ultrarapid metabolism converts ___________ to __________

Answer 0

Morphine to Codeine

Question 1

CYP2D6 deficiency leads to accumulation of which drugs?

Answer 1

Metoprolol
Codeine
Debrisoquine

Question 2

Which drug is lethal to individuals with G6PD enzyme deficiency?

Answer 2

Primaquine

Question 3

Succinylcholine causes prolonged apnea in the absence of this enzyme

Answer 3

Pseudocholinesterase

Question 4

Which enzyme is important for Isoniazid metabolism?

Answer 4

NAT II *5,6,7

Question 5

__________ cannot be converted into _________ in women with CYP2D6 polymorphism

Answer 5

Tamoxifen to Endoxifen

Question 6

Aminoglycoside given to patients with mitochondrial DNA polymorphism can lead to

Answer 6

Drug-induced deafness

Question 7

What is Allad 1?

Answer 7

Variant of lead metabolism involving genetic polymorphism

Question 8

If you get Alzheimer’s before the age of 40, you were either exposed to chemicals in utero or

Answer 8

Have paraoxanase gene polymorphism

Question 9

When given with this drug, patients with HIV who have HLA type B*5701will present with hypersensitivity reaction

Answer 9

Abacavir

Question 10

How do you avoid toxicity when giving Mercaptopurine to patients with Thiopurine methyltransferase (TPMT) deficiency?

Answer 10

Reduce the dose, you can only give 5% of the standard dose

Question 13

SANE Therapy

Answer 13

Safe
Affordable
Needed
Effective