Developmental Pharma

Question 0

Cytochrome P450 enzyme present after birth

Answer 0

CYP3A4

Question 1

Cytochrome P450 enzyme present in fetus

Answer 1

CYP3A7

Question 2

Nephrocalcinosis

Answer 2

Furosemide (Lasix)

Question 3

Renal failure, bowel perforation

Answer 3

Indomethacin (Indocin)

Question 4

Delayed development, growth supression

Answer 4

Adrenocorticoids

Question 5

Discolored teeth

Answer 5

Tetracyclin

Question 6

Hyperactivity, impaired intelligence

Answer 6

Phenobarbital

Question 7

Coarse features, thickened skull

Answer 7

Phenytoin

Question 8

Gray baby syndrome

Answer 8

Chloramphenicol

Question 9

Extrapyramidal reactions

Answer 9

Phenothiazines

Question 10

Hepatotoxicity

Answer 10

Valproic acid (Depakene)

Question 11

Reye’s syndrome

Answer 11

Aspirin

Question 12

Changes in gastro-intestinal absorption

Answer 12

Birth alkaline - after 24 hours drops to pH 1-3 - next 9-12 days rise again

Question 13

Histamine is not present in neonatal skin until

Answer 13

3 weeks

Question 14

In prematures, which has higher volume distribution, sulfonamides or lipophilic drugs?

Answer 14

Sulfonamides

Question 15

Plasma protein reach adult levels at how many years for acids and bases?

Answer 15

Acids - 3 years (shorter cause more similar to adult albumin)
Bases - 5-7 years

Question 16

Non-synthetic phase in hepatic ontogeny that REDUCES activity of drug

Answer 16

Phase I

Oxidation, hydrolysis, reduction, demethylation

Question 17

Synthetic phase in hepatic ontogeny that INACTIVATES the drug

Answer 17

Phase II

Conjugation, acetylation, methylation

Question 20

Most important metabolic pathway

Answer 20

Phase II Conjugation

Inc sulfatation
Dec glucoronidation and acetylation