Intro To CNS And Autonomic Pharma

Question 1

General CNS stimulants

Answer 1

Pentylenetetrazole

Methylxanthines

Question 2

Glycine antagonists that produce muscle spasms

Answer 2

Strychnine

Tetanus toxin

Question 3

GABA a anticonvulsants

Answer 3

Vigabatrine
Tiagabine
Gabapentine

Question 4

GABA a convulsants (inhibitors)

Answer 4

Muscimol
Bicuculline
Picrotoxin

Question 5

GABA a selective hypnotics

Answer 5

Benzodiazepines
Barbiturates
Zolpidem

Question 7

GABA b agonist to treat spasticity

Answer 7

Baclofen

Question 8

Blocks vesicular ach transporter

Answer 8

Vesamicol

Question 9

Prevents vesicular binding and release of ach

Answer 9

Botulinum toxin

Question 10

NMDA agonist that slows down Alzheimer’s

Answer 10

Memantine

Question 11

NMDA selective blockers

Answer 11

Ketamine

Phenylcyclidine

Question 12

Cholinesterase inhibitor that targets ach nicotinic receptor to treat myasthenia gravis

Answer 12

Pyridostigmine

Question 13

Cholinesterase inhibitor that targets achmuscarinic receptors to treat Alzheimer’s

Answer 13

Tacrine

Question 14

Opioid agonists that targets mu receptor for pain

Answer 14

Morphine

Codeine

Question 15

Opioid antagonist that targets mu receptor for intoxication

Answer 15

Naloxone

Question 16

Parkinson’s results from inc/dec dopamine

Psychosis and schizophrenia results from inc/dec dopamine

Answer 16

Parkinson’s = decreased dopamine

Psychosis and schizophrenia = increased dopamine

Question 17

Dopamine antagonist for psychosis

Answer 17

Haloperidol

Clozapine

Question 19

Dopamine agonists for Parkinson’s

Answer 19

L-dopa
Bromocriptine
Pergolide

Question 20

Used for hypertension but may cause depresssssssion

Answer 20

Reserpine (depletes serotonin and norepinepherin)

Question 21

Serotonin agonist for migraine

Answer 21

Sumatriptan

Question 22

Serotonin antagonist for migraine

Answer 22

Methysergide

Question 23

Serotonin related drugs targeting receptor 5HT3

Answer 23

Tricyclics
Ondasteron
Fluoxetine