Intro To Toxicology Flashcards
0
Q
Drugs that undergo enterohepatic recirculation
A
Carbamazepine Dapsone Phenobarbital Quinine Theophylline
1
Q
Treament of Isoniazid toxicity
A
Diazepam and Pyridoxine (Vitamin B6)
2
Q
Metabolite of Diazepam
A
Oxazepam
3
Q
Parent compound of NAPQI
A
Paracetamol
4
Q
NAPQI accumulation leads to liver toxicity, what do ypu give to reverse this?
A
Glutathione
5
Q
Effects of impaired membrane function:
Ethanol
Lipid solvents
Hydrocarbons
A
Ethanol : inc fluid permeability
Lipid solvents : kills plasma membrane
Hydrocarbons : kills lysosomal membrane
6
Q
Insecticides that induce allergic reactions
A
Pyrethroids
7
Q
Examples of beneficial pharmacological drug interactions
A
Naloxone and Opiates
Flumazenil and Benzodiazepine
8
Q
Inducers (induce own metabolism = reduced efficacy)
A
Barbiturates Imipramine Phenytoin Haloperidol Carbamazepine Rifampicin
9
Q
Inhibitors (don’t induce own metabolism = increased efficacy)
A
Cimetidine Chloramphenicol Isoniazid Phenothiazines Metronidazole TCADs
