Pharmacodynamics (Week 3) Flashcards
what is pharmacodynamics?
the effect of a drug when it binds
to its target
what factors affect how drugs interact with their target?
- Receptor type/activity/location
- Drug specificity
- Affinity
The dose of a drug that produces the desired effect in half of the subjects is called the drug’s
ED50
According to the DEA the most dangerous drugs are typically scheduled as
1
Most side effects are
predictable and mild
Which of the following drug names are capitalized?
trade
“Pharmacodynamic” tolerance occurs in the _______________; “metabolic” tolerance occurs in the ____________________.
synapse/neuron; liver
A drug that is more potent than another drug has
a smaller ED50
A drug that blocks the effect of the naturally occurring (endogenous) compound is called
an antagonist
The therapeutic index (TI) refers to the
relative safety of the drug
The observation that caffeine cannot exert as much central nervous system stimulation as amphetamine indicates that caffeine
is less efficacious than amphetamine.
Affinity refers to
the strength of attraction between a molecule (ligand) and it’s target (receptor)
