Antipsychotic Drugs (Week 4) Flashcards
Phenothiazines are in the class of antipsychotics known as
first-generation antipsychotics
Amisulpiride is a good choice of antipsychotic for patients who have a high risk for
diabetes
The most problematic side effect caused by clozapine is
agranulocytosis (low # of white blood cells in the blood)
What is the most common side effect of treatment with olanzapine?
weight gain
Which of the following is NOT a negative symptom of schizophrenia?
disorganized behavior
Which of the following is NOT a positive symptom of schizophrenia?
flat affect
The word tardive in tardive dyskinesia indicates that the symptoms
appear later in treatment
What is the primary indication of haloperidol?
psychosis
Loxapine is the only antipsychotic that
is administered via inhalation
An off-label use for risperidone is
OCD
what is the dopamine hypothesis of schizophrenia?
– Overactivity of DA synapses in mesolimbic pathway
– Seems to be related to the positive symptoms
what are problems with dopamine?
- 25% of patients do not respond to dopamine antagonists.
- Negative symptoms usually persist
- Blockade of DA receptors in striatum produces motor impairments (EPS, TD, dystonia)
- PCP produces symptoms similar to schizophrenia by blocking the NMDA glutamate receptor.
what is tardive diskinesia?
causes repetitive, involuntary movements, such as grimacing and eye blinking. irreversible.
what are the side effects of Butyrophenones?
High incidence of EPS (extrapyramidal side effects), particularly PD-like symptoms, dystonia, TD
what makes loxapine unqiue?
it comes in an inhaled version.
