Pharmacodynamics Cards Flashcards
The study of what the drug does to the body. The biochemical and physiological effects of drugs on the body or on microorganisms or parasites within or on the body and the mechanisms of drug action and the relationship between drug concentration and effect.
Pharmacodynamics
The study of what the body does to the drug. Rate at which the drug action begins, the duration of the effect, the chemical changes of the substance in the body, the effects and routes of excretion of the metabolites of the drug.
Pharmacodynamics
Effects that are meant to treat a disease or disorder.
Primary Therapeutic Effects
Effects that are meant to treat other desirable or undesirable effects.
Secondary Therapeutic Effects
What are four ways of classifying drugs?
By their specific pharmacological effect, by the route of injection, by the organ system they impact, by the receptors they bind to.
Receptor type which causes excitability changes in nerves, muscles such as local anaesthetics.
Ligand gated cell surface receptors
Receptor type which is a secondary messenger, multiplicity cascade effect, indirect effects via second messenger on cellular enzymes and metabolism such as adrenergenic and cholinergic receptors.
GTP or G protein coupled cell surface receptors
Receptor type which changes the rate of enzyme activity such as monoamine oxidase inhibitors.
Enzyme linked cell surface receptors.
Receptor type where drug can penetrate the membrane lypholylic. Binds an intracellular receptor that usually changes DNA transription to mRNA protein such as sexual steroids.
Intracellular receptors
Relationship the describes how a drug or toxic agents impact increases as overall exposure to substances increases and defines a drugs potency and effectiveness.
Dose-Effect relationship
In which two mechanisms do drugs exert their actions?
Alteration in cellular environment and cellular interaction.
What does an alteration in cellular environment include?
Physical, chemical and solvent effects.
What does cellular receptor drug interactions include?
Function of a cell alters when the drug binds with a reactive site within a cell. Drugs can have an affinity to a specific target cell components which have either agonistic or antagonistic qualities.
Drugs that bind to receptors and produce stimulatory responses that are similar to that produced by endogenous chemicals.
Agonists
Drugs that prevent agonists from binding to receptos, thus blocking their effects. Can be competitive and noncompetitive.
Antagonists
