pharmacodynamics and kinetics

Question 1

pharmacodynamics is

Answer 1

effects of drug and MOA

Question 2

pharmacokinetics is

Answer 2

what a body does to a drug

Question 3

elimination half life=

Answer 3

time taken for drug to reach half its concentration

Question 4

elimination rate

Answer 4

speed for drug to be eliminated

Question 5

why would a drug not have 100% bioavailability

Answer 5

solubility issues
efflux transporters
drug metabolising enzymes
first pass metabolism- all intestinal blood circulaton goes to liver first

Question 6

bioavailability=

Answer 6

fraction of unchanged drug reaching the systemic circulation after administration

Question 7

total exposure of a drug depends on what factors

Answer 7

elminstion rate
volume of distribution
bioavailability of fraction
dose

Question 8

what is ED50

Answer 8

Concentration required to achieve 50% of maximal effect

Question 9

what is LD50

Answer 9

letahl dose that will kill 50%

Question 10

what is therapeutic index

Answer 10

ratio of LD50 to ED50
TI > 10 IS GOOD
T1 < 10 can be prescribed