Pharmacodynamics Flashcards
Define Pharmacodynamics
This is how the drug acts on the body
Define Striking dose
This is defined as a large dose at the start of the treatment
List the mechanism of action sites
1= receptors (Transmembrane G protein-coupled receptors)
2=ion channels
3=enzymes
Where are receptors located
Cell membrane
cytoplasm
Nucleus
Define agonist
This is when a drug bind to a receptor and produces a maximum biological response
Define partial agonist
This is when a drug binds to a receptor and produces a response lower than an agonist
Define antagonists
This is a drug which inhibits a receptor site and prevents the binding of a drug to form a ligland. An example of this is naloxone this is antagonist of opioid
Competitive antagonist= binds to the agonist site of the receptor
non-competitive antagonist= binds to a different side of the receptor
Define intrinsic activity
This is the ability of a drug to cause effect after an action
Define affinity
The likeness of. a drug to create a lock and key mechanism
Define synergism
This is the interaction of two or more drugs to create a stronger result
Define summation
includes two drugs i.e
1+1=2 the affect does not exceeds the sum
Define synergism
This is when both drugs combined are less than the sum. i.e 1+1=1.5
Define potentiation
This is when the sum of the drug exceeds the sum. i.e 1+1+ 5
Define sensitisation
This is when two drugs causes a stronger affect
Define material accumulation
This is the increase of drug amount in the organism
