Antipsychotic Drugs

Question 1

What are 1st generation antipsychotic drugs (Tranquilizers )

Answer 1

These drugs have a high affinity to inhibit the domapine D2 receptor. Higher risk of developing extrapyramidal symptoms (effect motor function)

Question 2

What are 2nd generation antipsychotic drugs

Answer 2

We use 2nd generation

have fewer extrapyramidal symptoms (EPS) than the first-generation agents, but are associated with a higher risk of metabolic side effects, such as diabetes, hypercholesterolemia, and weight gain. The second-generation drugs appear to owe their unique activity to blockade of both serotonin 5-HT2A receptor and dopamine receptors and other receptors such as cholinergic, adrenergic and hitaminergic

Question 3

Where are the receptors found for Dopamine

Answer 3

The brain and the peripheries

Question 4

What are the use of antipsychotic drugs

Answer 4

reduce hallucinations associated with schizophrenia

reduce disruptive behaviour and extreme anxiety

Antiemetic (prevents nausea and vomiting)

Question 5

What are the side effect of antipsychotic drugs

Answer 5

anticholinergic effects

blocks a-adrenergic receptors

Sex dysfunction

Postural hypotension

Extrapyramidal symtoms

Sedation

Dry mouth

Arrhythmias and sudden cardiac death

Weight gain

Seizure

Question 6

List the antipsychotic drugs

Answer 6

Chlorpromazine

Sulpiride

Resperidone= D2, Serotonine, a-adrenoceptor and histamine-1 receptor agonist
Clozapine=  D2, Serotonine, a-adrenoceptor and muscarinic receptor agonist

Droperidol=1st generation

Doxylamine=1st generation

Other
Lithium (Bipolar)