Pharmaceutical Calculations Flashcards
What is a dose? What are 3 ways it is expressed?
the quantity of drug to be delivered to a patient to achieve an intended effect
- single dose: amount taken at one time
- daily dose: amount take daily
- total dose
How is the dosage rate expressed?
mg/kg OR mg/lb
What is a dosage regimen?
schedule of dosing
(e.g. three times daily for 7 days)
Dose is based on what 5 factors?
- biochemical and pharmacologic activity: ADME
- physical and chemical properties: hydrophilic, lipophilic
- dosage form used: tablet, capsule, transdermal patch
- route of administration: PO, IV
- patient factors: age, weight, body surface, liver and kidney function
How is a dose calculated?
How is the dose of most drugs used to treat neoplasms calculated?
according to body surface area (BSA) of the patient, which is correlated with the weight of the animal to convert an animal weight into BSA m^2
A 44-lb dog is to be treated for lymphosarcoma with vincristine sulfate, 2 mg/mL. The dose is 0.5mg/m^2. How many mLs will be given to the patient?
dose = (BSA of 44 lb dog) x (dose) / concentration of drug
dose = (0.74 m^2) x (0.5 mg/m^2) / 2 mg/mL
dose = 0.185 mL
