Exam 1 Review Flashcards
True or false: In first order kinetic elimination, the drug half-life decreases with time.
false
True or false: Drugs that are slowly eliminated require more frequent dosing.
false
True or false: The smaller the volume of distribution (Vd), the greater the distribution of the drug outside of the bloodstream.
false
True or false: Phase I metabolism of a drug always leads to its inactivation.
false
What is the main difference between passive and facilitated diffusion?
a. energy requirement
b. moving drugs against the concentration gradient
c. involvement of carriers or channels
C
Metabolism of drugs usually results in the….
a. formation of metabolites that are usually more polar
b. formation of metabolites that are less polar
c. formation of substances more active than the drug itself
d. liver toxicity
A
Which of the following is correct regarding a partial agonist?
a. it is a drug that is able to produce the full cell/tissue response
b. it is a drug that induces a response, but the maximum response is less than the maximum response to a full agonist
c. it is a drug that binds to the receptor, suppressing the receptor’s basal intrinsic activity
d. it is a drug that has high affinity for the receptor, but has no intrinsic activity
B
The first-pass effect is most apt to occur after which route of drug administration?
a. intravenous
b. intramuscular
c. subcutaneous
d. oral
e. inhalation
D
True or false: The larger the therapeutic index (TI), the safer the drug.
true
A 20-kg dog is dosed with 5 mg of drug X. If the half-life of drug X is 30 mins, how long will it take for the animal to have less than 1 mg of the drug remaining in the body?
a. 90 mins
b. 120 mins
c. 150 mins
d. 210 mins
A
The mechanism by which most drugs are absorbed following an intramuscular injection is….
a. passive transport
b. active transport
c. pinocytosis
d. facilitated diffusion
A
