Pharma Week 7

Question 1

What is road of administration of Gancyclovir

Answer 1

I.V
LOW oral bioavailability

Question 2

What is the SE of Gancyclovir (2)

Answer 2

Bone marrow suppression ( leukopenia 40% , thrombocytopenia 20%)

CNS effects ( coma , convulsions, headache, psychosis)

Question 3

3 uses of Foscarnet

Answer 3

• CMV retinitis ( including infections resistant to gancyclovir)
• H simplex resistant to acyclovir
• HIV

Question 4

4 SE of foscarnet

Answer 4

• Nephrotoxicity (25%)
• hypo
  Kalemia
  Calcemia
  Magnesemia

Question 5

2 SE of zidovudine

Answer 5

• Granulocytopenia , anemia in 45% of AIDS patients, or 5% in asymptomatic individuals
• CNS effects ( insomnia, nausea, myalgias, myopathy , peripheral neuropathy

Question 6

4. SE of didanosine

Answer 6

• pancreatitis
• peripheral neuropathy
• hyperuricemia
• liver dysfunction

Question 7

Lamivudine : 1 SE and 1 additional use

Answer 7

• SE : GIt effect
• uses : hepatitis B

Question 8

Mention 2 NNRTIs and the mechanism of action and 2 SE

Answer 8

1- efavirenz , nevirapine
2- bind to reverse transcriptase at site different to NRTIs bind to
3- rash , CNS( include vivid dreams)