pharma: antipsychotics Flashcards
mesocortical
negative symptoms
too little dopamine
mesolimbic
positive symptoms e.g. hallucinations
too much dopamine
nigostriatal pathway
dopamine hypoactivity can cause parkinsonin movements - rigidity, bradykinesia, tremor
typical antipsychotics
D2 dopamine receptor antagonists
high potency typicals
bind ot D2 receptor with high affinity
higher risk extrapyramidal side effects
high potency typicals examples
haloperidol
fluphenazine
low potency typicals
less affinity D2 receptors, more anticholingeric effects - sedation, hypotension
atypical antipsyhotics
serotonin-dopamine 2 antagonists
respiradone
extrapyramidal sideffects
weight gain
sedation
olanzapine
weight gain
quetiapiine
weight gain
orthostatic hypotension
clozapine indications
resistant patients
clozapine associations
agranuloctysosis
seizures, weight gain, abnormal LFTs
antipsychotic adverse effects
tardive dyskinesia neuroleptic malignant syndrome extrapyramidal side effects QT prolongation anticholinergic: dry mouth, sedation
tardive dyskinesia
involuntary muscle movemens
neuroleptic malignant syndrome
muscle rigidity fever alt mental status autonomic instability elevated WCC
extrapyramidal side effects
acute dystonia
parkinson syndrome
akathasia
anxiolytics
panic disorder
GAD
etc etc
benzodiazepines
insomnia, prasomnias, anxiety
benzodiazepine side effects
somnolence cog defects amnesia dishinhibition tolerance dependance
anulogranulocytosis
life threatening side effect of clozapine
really low white cell count
what can olanzapine cuase
hypoglycaemia
clozapine annual monitoring
weight
lipids
fasting blood glc
prolactin
benzodiazepine overdose Rx
flumenezil
