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psychiatry > pharma: antipsychotics > Flashcards

pharma: antipsychotics Flashcards

1
Q

mesocortical

A

negative symptoms

too little dopamine

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2
Q

mesolimbic

A

positive symptoms e.g. hallucinations

too much dopamine

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3
Q

nigostriatal pathway

A

dopamine hypoactivity can cause parkinsonin movements - rigidity, bradykinesia, tremor

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4
Q

typical antipsychotics

A

D2 dopamine receptor antagonists

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5
Q

high potency typicals

A

bind ot D2 receptor with high affinity

higher risk extrapyramidal side effects

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6
Q

high potency typicals examples

A

haloperidol

fluphenazine

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7
Q

low potency typicals

A

less affinity D2 receptors, more anticholingeric effects - sedation, hypotension

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8
Q

atypical antipsyhotics

A

serotonin-dopamine 2 antagonists

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9
Q

respiradone

A

extrapyramidal sideffects
weight gain
sedation

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10
Q

olanzapine

A

weight gain

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11
Q

quetiapiine

A

weight gain

orthostatic hypotension

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12
Q

clozapine indications

A

resistant patients

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13
Q

clozapine associations

A

agranuloctysosis

seizures, weight gain, abnormal LFTs

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14
Q

antipsychotic adverse effects

A 
tardive dyskinesia
neuroleptic malignant syndrome
extrapyramidal side effects
QT prolongation 
anticholinergic: dry mouth, sedation
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15
Q

tardive dyskinesia

A

involuntary muscle movemens

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16
Q

neuroleptic malignant syndrome

A 
muscle rigidity 
fever
alt mental status
autonomic instability 
elevated WCC
17
Q

extrapyramidal side effects

A

acute dystonia
parkinson syndrome
akathasia

18
Q

anxiolytics

A

panic disorder
GAD
etc etc

19
Q

benzodiazepines

A

insomnia, prasomnias, anxiety

20
Q

benzodiazepine side effects

A 
somnolence
cog defects
amnesia
dishinhibition 
tolerance
dependance
21
Q

anulogranulocytosis

A

life threatening side effect of clozapine

really low white cell count

22
Q

what can olanzapine cuase

A

hypoglycaemia

23
Q

clozapine annual monitoring

A

weight
lipids
fasting blood glc
prolactin

24
Q

benzodiazepine overdose Rx

A

flumenezil

psychiatry (20 decks)

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