Pharma Flashcards
Sublingual drug route
Lingual vein ⬇️ Internal jugular vein ⬇️ Brachiocephalic vein / innominate vein ⬇️ SVC ⬇️ RA
4 major factors affecting DRUG DISTRIBUTION
solubility
Organ size
Blood flow
Protein binding
Rate of elimination PROPORTIONATE TO CONCENTRATION
First order elimination
Rate of elimination constant REGARDLESS of concentration
Zero order concentration
Concentration decreases linearly over time
Drugs with ZERO ORDER KINETICS
WHAT PET?
Warfarin H heparin A aspirin T tolbutamide P phenytoin E ethanol T theophylline
Responsiveness diminishes rapidly after administration of a drug
Tachyphylaxis
drugs that display tachyphylaxis -9
MED Hoes Like Copulating Naked During Noon
M metroclopramide E ephedrine D dobutamine H hydralazine L lsd C calcitonin N nitroglycerin D desmopressin N nicotine
CYP450 inducers
Induce cyp450!! ➡️ dec drug concentration! Because drug is eliminated faster by cyp450
Can Eat Bulaga Gang Rape Paolo Someday?
C carbamazepine E ethanol B barbiturates G griseofulvin R rifampici P phenytoin S st johns wort/ smoking
Triad of Sjogren syndrome
Xerostomia - dry mouth
Xerophthalmia - dry eyes
Rheumatoid arthritis
Drug for smoking cessation
NICOTINE
Organophosphate poisoning sxs
“BASANG BASA!”
DUMBBELSS - 9
Diarrhea Urination Miosis Bradycardia Bronchospasm Excitation Lacrimation Sweating Salivation
HORNERS SYNDROME
PAM is HORneyyyy
P ptosis
A anhydrosis
M miosis
Non selective beta blockers that prolong survival in MI
TMP
Timolol
Metropolol
Propanolol
Non selective beta blockers that are effective in reducing mortality in Chronic Heart failure
MBC
metropolol
Bisprolol
Carvedilol
Thiazide Toxicity
HYPER GLUC
GLYCEMIA
LIPIDEMIA
URICEMIA
CALCEMIA
